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Funding:
This work was supported by U.S. NIH (DK099558, CA233794, CA222900, CA230694, CA255621), European Commission (ERC-2014-AdG-671231, ERC-AdG-2020-101021417), Cancer Prevention and Research Institute of Texas (RR180016, RP200554) to Y.H.
Conflicts of interest
These authors disclose the following: Y.H. serves as an advisory board member for Helio Genomics, Espervita Therapeutics, and Roche Diagnostics, a shareholder for Alentis Therapeutics and Espervita Therapeutics, and receive research support from Allergan/AbbVie, Kyowa Kirin, and Morphic Therapeutics. The remaining authors disclose no conflicts.
Author contributions
Naoto Fujiwara (Conceptualization, Methodology, Software, Formal analysis, Data Curation, Writing - Original Draft, Visualization); Naoto Kubota (Data Curation); Shijia Zhu (Formal analysis), Shigeki Nakagawa (Resources, Data Curation), Hideo Baba (Resources, Data Curation); Yujin Hoshida (Conceptualization, Methodology, Validation, Writing - Review & Editing, Funding acquisition).
Data transparency statement
All data are publicly available at the NCBI GEO (accession number, GSE193080, GSE214435). The research team will provide an email address for communication once the information sharing is approved. The proposal should include detailed aims, statistical plan, and other information/materials to guarantee the rationality of requirement and the security of the data. The related patient data will be shared after review and approval of the submitted proposal and any related requested materials. Of note, data with patient names and other identifiers cannot be shared.
Ethical Statement: The corresponding author, on behalf of all authors, jointly and severally, certifies that their institution has approved the protocol for any investigation involving humans or animals and that all experimentation was conducted in conformity with ethical and humane principles of research.
Reporting Guidelines: Helsinki Declaration
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