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Original Research—Clinical|Articles in Press

Health state questionnaires deployed in ulcerative colitis patients: the medical, psychological and economic perspective

Open AccessPublished:March 17, 2023DOI:https://doi.org/10.1016/j.gastha.2023.03.020
Health state questionnaires deployed in ulcerative colitis patients: the medical, psychological and economic perspective
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      Abstract

      Background and aims

      To determine how the health state of ulcerative colitis patients is impacted by their disease different health state questionnaires are deployed. This study examines to what extent these health state questionnaires determine the same underlying health state concept, and to what extent the complementary use of the health state questionnaires has added value for physicians.

      Methods

      In total, 307 patients were enrolled in this cross-sectional multicentre cohort study. Medical, psychological, economic and composite health state questionnaires were administered to determine reliability, convergent validity and explained variance. Reliability was determined using Cronbach’s alpha. Convergent validity was measured using Spearman correlation coefficients. Explained variance was interpreted using R-squared coefficients.

      Results

      All questionnaires can be considered reliable. The medical, psychological and economic health state questionnaires show weak to moderate convergent validity with each other. The medical, psychological and economic health state questionnaires also explain limited variance in each other’s outcomes. The composite health state questionnaire shows moderate to strong convergent validity with the other health state questionnaires. The composite health state questionnaire further explains considerable variance in the outcomes of the other health state questionnaires.

      Conclusion

      Deploying divergent medical, psychological and economic health state questionnaires may have added value as they provide a multi-perspective holistic insight into patients’ health states. Deploying the composite health state questionnaire combined with other health state questionnaires may have added value as it provides additional understanding of their outcomes. Deploying an independent psychological health state questionnaire may have added value as it shows particularly limited convergent validity and explained variance regarding other health state questionnaires.

      Keywords

      Article info

      Publication history

      Accepted: March 15, 2023
      Received in revised form: March 7, 2023
      Received: October 30, 2022

      Publication stage

      In Press Accepted Manuscript

      Footnotes

      Conflicts of interest

      The authors disclose no conflicts.

      Author contributions

      DSEB designed and wrote the manuscript. TEHR and SB supervised this study. PWAT and MGVM provided the data. All authors read and revised the manuscript. All authors approved the final manuscript.

      Funding

      The authors report no funding.

      Data transparency statement

      The database can be made available from corresponding author upon reasonable request and with permission of the IBDREAM registry.

      Ethical Statement:

      The corresponding author, on behalf of all authors, jointly and severally, certifies that their institution has approved the protocol for any investigation involving humans or animals and that all experimentation was conducted in conformity with ethical and humane principles of research.

      Reporting Guidelines:

      SAGER, STROBE

      Identification

      DOI: https://doi.org/10.1016/j.gastha.2023.03.020

      Copyright

      © 2023 Published by Elsevier, Inc on behalf of the AGA Institute

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