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A Review of the Clinical Presentation, Outcomes and Treatments of Patients Having Desmoid Tumors

  • Author Footnotes
    ∗ Author
    Carlos Figueredo
    Correspondence
    Correspondence: Carlos J. Figueredo Gastroenterology Fellow Montefiore Medical Center – Department of Gastroenterology and Hepatology (Tel: 312-307-0520)
    Footnotes
    ∗ Author
    Affiliations
    Department of Gastroenterology and Hepatology, Montefiore Medical Center/Albert Einstein College of Medicine. New York, NY
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    ∗∗ Co-author
    Thomas Schiano
    Footnotes
    ∗∗ Co-author
    Affiliations
    Recanati-Miller Transplantation Institute, The Mount Sinai Medical Center. New York, NY
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    ∗ Author
    ∗∗ Co-author
Open AccessPublished:January 20, 2023DOI:https://doi.org/10.1016/j.gastha.2023.01.010
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      Abstract

      Desmoid tumors (DT) are deep fibroblastic neoplasms that arise from musculo-aponeurotic stromal elements. DTs may result in significant morbidity by infiltrating vital anatomic structures. Their mortality is often due to the local aggressiveness, most commonly when intra-abdominal in location. Some indolent DTs can be observed expectantly; infiltrative tumors require an aggressive and multidisciplinary approach and are offered conservative therapies such as non-steroidal anti-inflammatories or antiestrogens when surgery is not feasible. Comparably, chemotherapy is considered for those cases not amenable to surgery or radiation. Bowel resection and at times intestinal transplantation may be necessary. However, DTs may recur post-surgery making long term management of these patients. Herein, we review the genetics, clinical presentations, and outcomes, as well as treatments of DTs.

      Keywords