Background and Aims
Abbreviations used in this paper:CRC (colorectal cancer), CT (computed tomography), FDR (first-degree relative), SDR (second-degree relative), TDR (third-degree relative)
|Female gender||46 (69.7)|
|White (non-Hispanic)||63 (95.5)|
|Black or African American||2 (3)|
|Ashkenazi Jewish||6 (9)|
|Ashkenazi Jewish||5 (7.5)|
|Any smoking history||21 (33.3)|
|Current smokers||6 (9.5)|
|Pack years||25.3 ± 5.7 (range 2–75, median 15)|
|Any alcohol consumption||41 (65)|
|Active—between 1–7 drinks per wk regularly||19 (30.1)|
|Usage of potential chemopreventive medication|
Familial Malignancy Burden
|MUTYH (Y179C and G396D mutations only)||2||4.76|
Colonoscopy Findings and CRC Burden
|Patient ID||Age at 1st colon.||Age CRC||CRC location (surgical procedure)||MMR status||CRC stage||Surv. interval (mo) to CRC|
|Adenoma burden||Total surv. interval (mo)||CRC age father||CRC age mother||No. of SDR with CRC||Age CRC SDR |
|49||No data||45||No data||No data||No data||No data||No data||No data||55||45||0||NA|
|A. Categorical variables|
|Parameter||CRC (N = 6)||No CRC (N = 60)||Fisher's exact test sig. (2-sided)|
|Gender (F)||4 (66.7%)||42 (70%)||1|
|Amsterdam+||3 (50%)||9 (15%)||0.068|
|EOCRC in parent||4 (66.7%)||7 (11.7%)||0.18|
|CRC in SDR||2 (33.3%)||26 (43.3%)||1|
|CRC in TDR||1 (16.7%)||7 (11.7%)||0.55|
|Smoking Hx.||4 (66.7%)||17 (29.8%)||0.08|
|Alcohol use||2 (33.3%)||39 (68.4%)||0.17|
|B. Scaled variables|
|Parameter||Patients with CRC||Patients without CRC||Mann-Whitney U value||Test sig. (2-sided)|
|Age at first colonoscopy (y)|
|59 (46–68)||46 (35–57)||115||0.03|
|Total number of colonoscopies||4|
|Adenoma burden||1 (0–7)||1 (0–62)||111||0.83|
|Earliest age of CRC in parent (y)||60 (48–72)||62.5 (35–84)||98||0.8|
- Ness R.
- Llor X.
- Cassara C.
- et al.
- Tables A1–A7
- Cancer statistics.CA Cancer J Clin. 2020; 70: 7-30
- Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland.N Engl J Med. 2000; 343: 78-85
- Familial colorectal cancer: a review.World J Gastroenterol. 2014; 20: 9292-9298
- Optimal vitamin D status for colorectal cancer prevention: a quantitative meta analysis.Am J Prev Med. 2007; 32: 210-216
- Diabetes mellitus and the incidence and mortality of colorectal cancer: a meta-analysis of 24 cohort studies.Colorectal Dis. 2012; 14: 1307-1312
- Obesity and risk of colorectal cancer: a systematic review of prospective studies.PLoS One. 2013; 8: e53916
- Alcohol intake, beverage choice, and cancer: a cohort study in a large kaiser permanente population.Perm J. 2015; 19: 28-34
- Meta-analysis of prospective cohort studies of cigarette smoking and the incidence of colon and rectal cancers.Eur J Cancer Prev. 2015; 24: 6-15
- A systematic review and meta-analysis of familial colorectal cancer risk.Am J Gastroenterol. 2001; 96: 2992-3003
- Population-based family history-specific risks for colorectal cancer: a constellation approach.Gastroenterology. 2010; 138: 877-885
- Family history and the natural history of colorectal cancer: systematic review.Genet Med. 2015; 17: 702-712
- Relative and absolute risk of colorectal cancer for individuals with a family history: a meta-analysis.Eur J Cancer. 2006; 42: 216-227
- ACG clinical guidelines: colorectal cancer screening 2021.Am J Gastroenterol. 2021; 116: 458-479
- Colorectal cancer screening: recommendations for physicians and patients from the U.S. multi-society task force on colorectal cancer.Am J Gastroenterol. 2017; 112: 1016-1030
- NCCN guidelines version 1.2022 colorectal cancer screening.
- Outcomes of screening and surveillance in people with two parents affected by colorectal cancers: experiences from the familial bowel cancer service.Hered Cancer Clin Pract. 2019; 17: 1-9
- Effects of family history on relative and absolute risks for colorectal cancer: a systematic review and meta-analysis.Clin Gastroenterol Hepatol. 2019; 17: 2657-2667.e9
- Incidence and mortality of colorectal cancer in individuals with a family history of colorectal cancer.Gastroenterology. 2015; 149: 1438-1445.e1
- Screening for colorectal cancer: US preventive services task force recommendation statement.JAMA. 2021; 325: 1965-1977
Authors' Contributions: Dan Feldman (conceptualization and design: lead; formal analysis and interpretation: lead; investigation: lead; resources and acquisition of data: equal; methodology: equal; visualization: lead; writing original draft: equal; writing, revising, and editing the draft critically for important intellectual content: lead). Linda Rodgers-Fouche (conceptualization: equal; resources and acquisition of data: lead; writing, revising, and editing the draft critically for important intellectual content: supporting). Daniel C. Chung (conceptualization and design: lead; formal analysis and interpretation: lead; investigation: lead; methodology: lead; resources and acquisition of data: equal; supervision: lead; visualization: equal; writing original draft: lead; writing, revising, and editing the draft critically for important intellectual content: lead). All authors read and approved the final manuscript.
Conflicts of Interest: The authors disclose no conflicts.
Funding: The authors report no funding.
Ethical Statement: The corresponding author, on behalf of all authors, jointly and severally, certifies that their institution has approved the protocol for any investigation involving humans or animals and that all experimentation was conducted in conformity with ethical and humane principles of research.
Data Transparency Statement: Data are unavailable due to patient privacy restrictions and the absence of consent for public sharing.
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