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Eosinophilic Gastritis Mimicking Mucosa-Associated Lymphoid Tissue Lymphoma

  • Kimitoshi Kubo
    Correspondence
    Correspondence: Address correspondence to: Kimitoshi Kubo, MD, Department of Gastroenterology, National Hospital Organization Hakodate National Hospital, 18-16 Kawahara-cho, Hakodate, Hokkaido 041-8512, Japan.
    Affiliations
    Department of Gastroenterology, National Hospital Organization Hakodate National Hospital, Hakodate, Hokkaido, Japan
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  • Noriko Kimura
    Affiliations
    Department of Pathology, National Hospital Organization Hakodate National Hospital, Hakodate, Hokkaido, Japan
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Open AccessPublished:June 14, 2022DOI:https://doi.org/10.1016/j.gastha.2022.06.006
      A 37-year-old man was referred to our hospital for epigastric pain. Laboratory findings showed a mildly elevated eosinophil count and negativity for serum Helicobacter pylori immunoglobulin G antibody. In the greater curvature of the gastric upper body, esophagogastroduodenoscopy revealed a pale, ill-demarcated, slightly depressed lesion presenting as a reddish granular mucosa in its internal area on white light imaging (Figure A). Linked color imaging (LCI) highlighted the lesion as a purple-colored depressed lesion presenting as an orangish granular mucosa in its internal area (Figure B), and blue laser imaging highlighted the pale area as whitish (Figure C). A histopathologic examination of biopsy specimens, performed for differential diagnosis of mucosa-associated lymphoid tissue lymphoma and eosinophilic gastritis (EG), showed marked infiltration of eosinophils (≥20/high power field) (Figure D). The patient was diagnosed with EG and treated with prednisolone.